Currently viewing the tag: "clinical study"

autoinjectorA study of 102 patients enrolled from adult and pediatric clinics showed that only 16% used their epinephrine auto-injectors correctly. Of the remaining 84%, more than half missed 3 or more steps for proper administration.

The most common errors included:

  • Failure to hold the unit in place for at least 10 seconds after triggering
  • Failure to place the needle end of the device on the thigh, and
  • Failure to depress the device forcefully enough to activate the injection.

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baby

A study of 12 one year old babies with food allergies conducted at the Murdoch Children’s Research Institute in Victoria, Australia has found preliminary evidence that children may acquire allergies prior to birth.

The study measured DNA methylation – a mechanism that determines how genes are switched on or off – in the babies’ blood samples. “We found several switches that were different in the children with food allergies that occurred in some important immune genes”, said Dr David Martino from the Institute.

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ncstate

As many of our readers are well aware, peanuts are the leading cause of severe food-related allergic reactions in the US. Though Oral Immunotherapy (OIT) and related treatments that expose the subject to flour containing small, but increasing amounts of peanut protein are showing promise, there is a danger of anaphylactic reaction throughout the therapy.

Researchers at North Carolina State University’s Plants for Human Health Institute are experimenting with new therapy media that combine the traditional peanut flour used in OIT with plant polyphenols found in many fruits and vegetables. When the peanut protein in the flour is bound to polyphenols derived from plants like blackcurrant, cinnamon, cranberry and green tea, they appear to become much less allergenic in lab tests. Tests in mice with a cranberry derivative/peanut flour combination appeared to trigger the desired desensitization without the dangerous reactions that can occur.

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CHOP LogoA study presented at the 2014 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI), asserts that individuals who have outgrown a food allergy may be at risk of developing eosinophilic esophagitis (EoE) to the same food.

“EoE is characterized by the presence of large numbers of white blood cells called eosinophils in the tissue of the esophagus, which causes inflammation or swelling of the esophagus,” said Jonathan M. Spergel, MD, PhD, FAAAAI, one of the study authors. “Foods like dairy products, egg, soy and wheat are main causes of EoE.”

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cambridge

The results of a 3 year study of the effectiveness of Oral Immunotherapy (OIT) for desensitization of peanut allergy in children was published today in the medical journal The Lancet.

The study, co-sponsored by the University of Cambridge and Addenbrooke’s Hospital, followed 85 children aged 7-16 with confirmed peanut allergy from January 2010 through March 2013.

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AAAAI

According to US News and World Report, a study presented this week at a meeting of the American College of Allergy, Asthma and Immunology (ACAAI) described the case of a boy who was cured of his peanut allergy after a bone marrow transplant.

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Xolair

A pilot study conducted at Boston Children’s Hospital Division of Allergy and Immunology and Harvard Medical School shows promise that treatment combining the asthma drug Xolair® with oral desensitization therapy facilitates rapid desensitization in children with severe peanut allergies.

The study, published in the Journal of Allergy and Clinical Immunology (JACI), followed 8 boys and 5 girls aged 8-16 years with histories of significant allergic reactions to peanuts.

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US House

FARE has issued an advisory regarding the effect of the current partial shutdown of the Federal Government on those with food allergies.

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JohnsHopkinsLogo

Recently published research in Science Translational Medicine shows that defective genes known to play a role in connective tissue disorders also plays a significant role in the development of allergies.

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AAAAI

FARE reports that the American Academy of Allergy, Asthma and Immunology and the European Academy of Allergy and Clinical Immunology have issued a consensus report on the current state of allergen immunotherapy (AIT).

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