Get the Flu Vaccine with an Egg Allergy? The CDC Answers Your Questions

The Center for Disease Control (CDC) recommends getting the flu shot by the end of October for all people aged 6 months and older with a few rare exceptions. And those with an egg allergy are generally not excluded.

We’ve pulled the following questions and answers from Flu Vaccine and People with Egg Allergies, the CDC’s recommendations published at the end of 2017 for 2018.


What is considered an egg allergy? What are the signs and symptoms of an egg allergic reaction?

Egg allergy can be confirmed by a consistent medical history of adverse reactions to eggs and egg-containing foods, plus skin and/or blood testing for immunoglobulin E antibodies to egg proteins. Persons who are able to eat lightly cooked egg (e.g., scrambled egg) without reaction are unlikely to be allergic. Egg-allergic persons might tolerate egg in baked products (e.g., bread or cake). Therefore, tolerance to egg-containing foods does not exclude the possibility of egg allergy. Egg allergies can range in severity.

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How common is egg allergy in children and adults?

Egg allergy affects about 1.3 % of all children and 0.2 % of all adults.

What vaccine should I get if I am egg allergic, but I can eat lightly cooked eggs?

If you are able to eat lightly cooked egg (e.g., scrambled egg) without reaction, you are unlikely to be allergic and can get any licensed flu vaccine (i.e., any form of IIV, LAIV, or RIV) that is otherwise appropriate for your age and health status.

What flu vaccine should I get if I get hives after eating egg-containing foods?

If you are someone with a history of egg allergy, who has experienced only hives after exposure to egg, you can get any licensed flu vaccine (i.e., any form of IIV, LAIV, or RIV) that is otherwise appropriate for your age and health.

What kind of flu vaccine should I get if I have more serious reactions to eating eggs or egg-containing foods like cardiovascular changes or a reaction requiring epinephrine?

If you are someone who has more serious reactions to eating eggs or egg-containing foods, like angioedema, respiratory distress, lightheadedness, or recurrent emesis; or who required epinephrine or another emergency medical intervention, you can get any licensed flu vaccine (i.e., any form of IIV, LAIV, or RIV) that is otherwise appropriate for your age and health status, but the vaccine should be given by a health care provider who can recognize and respond to a severe allergic response.

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Are there still people with egg allergies who should not get flu vaccine?

People with egg allergy can receive flu vaccines according to the recommendations above. A person who has previously experienced a severe allergic reaction to flu vaccine, regardless of the component suspected of being responsible for the reaction should not get a flu vaccine again.

Why do flu vaccines contain egg protein?

Most flu vaccines today are produced using an egg-based manufacturing process and thus contain a small amount of egg protein called ovalbumin.

How much egg protein is in flu vaccine?

While not all manufacturers disclose the amount of ovalbumin in their vaccines, those that did from 2011–12 through 2014–15 reported maximum amounts of ≤1 µg/0.5 mL dose for flu shots and 0.24 µg/0.2 mL dose for the nasal spray vaccine. Cell-based flu vaccine (Flucelvax) likely has a much smaller amount of egg protein since the original vaccine virus is grown in eggs, but mass production of that vaccine does not occur in eggs. Recombinant vaccine (Flublok) is the only vaccine currently available that is completely egg free.

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Can egg protein in flu vaccine cause allergic reactions in persons with a history of egg allergy?

Yes, allergic reactions can happen, but they occur very rarely with the flu vaccines available in the United States today. Occasional cases of anaphylaxis, a severe life-threatening reaction that involves multiple organ systems and can progress rapidly, in egg-allergic persons have been reported to the Vaccine Adverse Event Reporting System (VAERS) after administration of flu vaccine. Flu vaccines contain various components that may cause allergic reactions, including anaphylaxis. In a Vaccine Safety Datalink study, there were 10 cases of anaphylaxis after more than 7.4 million doses of inactivated flu vaccine, trivalent (IIV3) given without other vaccines, (rate of 1.35 per one million doses). Most of these cases of anaphylaxis were not related to the egg protein present in the vaccine. CDC and the Advisory Committee on Immunization Practices continue to review available data regarding anaphylaxis cases following flu vaccines.

How long after flu vaccination does a reaction occur in persons with a history of egg allergy?

Allergic reactions can begin very soon after vaccination. However, the onset of symptoms is sometimes delayed. In a Vaccine Safety Datalink study of more than 25.1 million doses of vaccines of various types given to children and adults over 3 years, only 33 people had anaphylaxis. Of patients with a documented time to onset of symptoms, eight cases had onset within 30 minutes of vaccination, while in another 21 cases, symptoms were delayed more than 30 minutes following vaccination, including one case with symptom onset on the following day.

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