Epinephrine is the only drug that can halt the progression of anaphylaxis, a severe, life-threatening allergic reaction.
Sufficient supplies of the drug are critical to the food allergy community, whether provided via devices intended for use by individuals or those intended for administration by trained practitioners.
The Food and Drug Administration (FDA) maintains a database of drugs that are in short supply. Though epinephrine is currently readily available, emergency devices from specific manufacturers are experiencing sporadic shortages.
The following table indicates the availability of epinephrine auto-injectors and prefilled syringes intended for use by individuals:
Supply of Emergency Epinephrine Devices
(auto-injector or prefilled syringe)
Adamis Pharmaceuticals Corporation (Reverified 12/17/2019) | ||||
| Product | Availability | Related Info | Reason | |
| SYMJEPI 0.3mg single-dose, pre-filled syringe | Available | |||
| SYMJEPI 0.15mg single-dose, pre-filled syringe | Available | |||
Impax Laboratories (Revised 12/13/2019) | ||||
| Product | Availability | Related Info | Reason | |
| “Adrenaclick Generic” 0.15mg auto-injector | On allocation to current customers | See FDA site for more information including extension of expiration dates | Manufacturing delays | |
| “Adrenaclick Generic” 0.3mg auto-injector | On allocation to current customers | See FDA site for more information including extension of expiration dates | Manufacturing delays | |
Kaleo (Reverified 03/18/2020) | ||||
| Product | Availability | Related Info | Reason | |
| AUVI-Q 0.3mg auto-injector | Available | AUVI-Q is readily available and not currently in shortage. | ||
| AUVI-Q 0.15mg auto-injector | Available | AUVI-Q is readily available and not currently in shortage. | ||
| AUVI-Q 0.1mg auto-injector | Available | AUVI-Q is readily available and not currently in shortage. | ||
Mylan Specialty (Revised 03/24/2020) | ||||
| Product | Availability | Related Info | Reason | |
| EpiPen® and Generic 0.3mg auto-injector | Available (though supplies vary) | Meridian Medical Technologies, a subsidiary of Pfizer that manufactures EpiPen® and the authorized generic version, continues to experience manufacturing constraints. Currently, supplies will vary from pharmacy to pharmacy. Mylan, the distributor, is expediting shipments to wholesalers upon receipt from Pfizer. Patients who are experiencing difficulty accessing product should continue to contact Mylan Customer Relations at 800-796-9526 for assistance in locating alternative pharmacies. See FDA site for more information including extension of expiration dates | Manufacturing delays | |
| EpiPen® and Generic 0.15mg auto-injector | Available (though supplies vary) | Meridian Medical Technologies, a subsidiary of Pfizer that manufactures EpiPen® and the authorized generic version, continues to experience manufacturing constraints. Currently, supplies will vary from pharmacy to pharmacy. Mylan, the distributor, is expediting shipments to wholesalers upon receipt from Pfizer. Patients who are experiencing difficulty accessing product should continue to contact Mylan Customer Relations at 800-796-9526 for assistance in locating alternative pharmacies. See FDA site for more information including extension of expiration dates | Manufacturing delays | |
Teva Pharmaceuticals (Revised 03/17/2020) | ||||
| Product | Availability | Related Info | Reason | |
| Generic EpiPen Equivalent 0.15mg auto-injector | Available but sporadic supply interruptions through June 2020 | |||
| Generic EpiPen Equivalent 0.3mg auto-injector | Available but sporadic supply interruptions through June 2020 | |||
If you experience difficulty finding your specific emergency epinephrine device, follow the instructions provided in the Related Info column above or consider switching to a brand that is readily available. You can find a summary of the current options along with usage instruction videos by clicking here.
The following table indicates shortages of prefilled epinephrine syringes intended for use by trained practitioners:
Supply of Epinephrine Syringes for Trained Practitioners
Amphastar Pharmaceuticals, Inc./IMS (Reverified 03/30/2020) | ||||
| Product | Availability | Related Info | Reason | |
| 10mL Luer-Jet Prefilled Syringe | Intermittent Supply | IMS is releasing product, but market demand continues to exceed our capacity | Demand increase for the drug | |
Hospira, Inc. (Reverified 03/25/2020) | ||||
| Product | Availability | Related Info | Reason | |
| 1mg/10mL LifeShield Abboject Glass Syringe | Limited Supply Available. Next Delivery: March 2020; Estimated Recovery: August 2020 | Check Wholesaler for Availability Shortage per Manufacturer See FDA site for more information including extension of expiration dates | Manufacturing delays | |
- Current and Resolved Drug Shortages and Discontinuations Reported to FDA: Epinephrine Injection, Auto-Injector — Food and Drug Administration
- Current and Resolved Drug Shortages and Discontinuations Reported to FDA: Epinephrine Injection, 0.1 mg/mL — Food and Drug Administration
Help Finding Allergy-Friendly Foods: #SnackSafelyAtHome
