HomeEmerging TherapyFDA Accepts Investigational New Drug Application for Novel Peanut Allergy Therapy

FDA Accepts Investigational New Drug Application for Novel Peanut Allergy Therapy

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COUR Pharmaceuticals, a company based in Elmhurst, Illinois, is developing first-in-class therapies designed to reprogram the immune system to achieve antigen-specific tolerance for immune-mediated diseases.

The company, which is already in phase 2 clinical trials with a treatment for celiac disease, has announced the FDA has accepted their Investigational New Drug (IND) application for evaluation of CNP-201, a treatment for peanut allergy. that reduces the need for strict peanut avoidance and reduces the potentially fatal health risks associated with peanut allergy.

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Said John J Puisis, co-founder, president & CEO of COUR:

This will be the first clinical trial with a first-in-class therapy to reprogram the immune system to stop the allergic response to peanuts. Our hope is the clinical trials will confirm that CNP-201 can help eliminate the potentially fatal health risks associated with patients who have a peanut allergy.

CNP-201 is a biodegradable nanoparticle encapsulating purified peanut protein extract and administered through intravenous infusion. The nanoparticles containing peanut allergens are consumed by immune-presenting cells. When the particles and allergens are presented by the immune presenting cell, they trigger a reprogramming of the cellular functions of the immune system, reducing and possibly eliminating the potential risk of severe allergic reactions.

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Said Dr Kari Nadeau, Director, and Dr Sharon Chinthrajah Clinical Research Director of the Sean N Parker Center for Allergy and Asthma Research at Stanford University:

Our team were early supporters of the potential of COUR’s immune reprogramming platform, so we’re eager to see data showing CNP-201 can reprogram T cells, shut down B cells, and protect the allergy patient from continual B cell production of IgE and associated allergic cytokines, which are so deleterious to patients’ quality-of-life.

Peanut allergy is the most common food allergy in children under age 18 and the second-most common food allergy in adults. A recent study in the Journal of Allergy and Clinical Immunology found that as many as 4.6 million US adults are allergic to peanuts.

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Here’s a video illustrating how the COUR platform introduces an allergen to the immune system and retrains it to see that allergen as not harmful:


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Dave Bloom
Dave Bloom is CEO and "Blogger in Chief" of SnackSafely.com.

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